Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
Identifieur interne : 000A60 ( Main/Exploration ); précédent : 000A59; suivant : 000A61Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses
Auteurs : Carolien E. Van De Sandt ; Joost H. C. M. Kreijtz ; Guus F. RimmelzwaanSource :
- Viruses [ 1999-4915 ] ; 2012.
Abstract
The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.
Url:
DOI: 10.3390/v4091438
PubMed: 23170167
PubMed Central: 3499814
Affiliations:
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Rimmelzwaan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23170167</idno><idno type="pmc">3499814</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499814</idno><idno type="RBID">PMC:3499814</idno><idno type="doi">10.3390/v4091438</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000E28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E28</idno><idno type="wicri:Area/Pmc/Curation">000E28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E28</idno><idno type="wicri:Area/Pmc/Checkpoint">000727</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000727</idno><idno type="wicri:Area/Ncbi/Merge">000840</idno><idno type="wicri:Area/Ncbi/Curation">000840</idno><idno type="wicri:Area/Ncbi/Checkpoint">000840</idno><idno type="wicri:Area/Main/Merge">000A61</idno><idno type="wicri:Area/Main/Curation">000A60</idno><idno type="wicri:Area/Main/Exploration">000A60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evasion of Influenza A Viruses from Innate and Adaptive Immune Responses</title><author><name sortKey="Van De Sandt, Carolien E" sort="Van De Sandt, Carolien E" uniqKey="Van De Sandt C" first="Carolien E." last="Van De Sandt">Carolien E. Van De Sandt</name></author><author><name sortKey="Kreijtz, Joost H C M" sort="Kreijtz, Joost H C M" uniqKey="Kreijtz J" first="Joost H. C. M." last="Kreijtz">Joost H. C. M. Kreijtz</name></author><author><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The influenza A virus is one of the leading causes of respiratory tract infections in humans. Upon infection with an influenza A virus, both innate and adaptive immune responses are induced. Here we discuss various strategies used by influenza A viruses to evade innate immune responses and recognition by components of the humoral and cellular immune response, which consequently may result in reduced clearing of the virus and virus-infected cells. Finally, we discuss how the current knowledge about immune evasion can be used to improve influenza A vaccination strategies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author><author><name sortKey="Shaw, M L" uniqKey="Shaw M">M.L. Shaw</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Stohr, K" uniqKey="Stohr K">K. Stohr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jagger, B W" uniqKey="Jagger B">B.W. Jagger</name></author><author><name sortKey="Wise, H M" uniqKey="Wise H">H.M. 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Kang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Kreijtz, Joost H C M" sort="Kreijtz, Joost H C M" uniqKey="Kreijtz J" first="Joost H. C. M." last="Kreijtz">Joost H. C. M. Kreijtz</name><name sortKey="Rimmelzwaan, Guus F" sort="Rimmelzwaan, Guus F" uniqKey="Rimmelzwaan G" first="Guus F." last="Rimmelzwaan">Guus F. Rimmelzwaan</name><name sortKey="Van De Sandt, Carolien E" sort="Van De Sandt, Carolien E" uniqKey="Van De Sandt C" first="Carolien E." last="Van De Sandt">Carolien E. Van De Sandt</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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